Current positions

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Tallac Therapeutics Inc., is a privately held immuno-oncology company advancing innovative therapeutic approaches in disease areas of unmet medical needs. Our core technology platform enables us to discover and develop next generation protein therapeutics for targeted immune activation, harnessing the power of innate and adaptive immunity to fight cancer. We are currently advancing a pipeline of novel Toll-like Receptor Agonist Antibody Conjugate (TRAAC) molecules towards clinical development. We are looking for a talented and highly motivated Sr. Scientist to join to join our Research team. The successful candidate will contribute to the discovery of antibody therapeutics and development of novel technologies.

Responsibilities

  • Leverage knowledge of medicinal chemistry, bioconjugation, and protein engineering to develop novel antibody conjugate therapeutic technologies.
  • Evaluate and optimize conjugation and protein design strategies utilizing novel chemistries and payloads to produce best in class oligonucleotide antibody conjugates.
  • Linker-payload design and management of external chemistry resources.
  • Partner with colleagues in Protein Science, Biology, and CMC to drive project progression.
  • Synthesis, purification, and characterization of antibody conjugates on research- and early development scales.
  • Efficiently accomplish project goals on time and
  • Stay scientifically current, and implement new technologies to enhance protein chemistry capabilities and develop novel platforms.

Qualifications

  • Ph.D. in Organic Chemistry/ Biochemistry/Chemical Biology or other relevant discipline with 2+ years of relevant experience.
  • Strong background in chemistry and ability design and troubleshoot linker payload generation at CROs
  • Experience with oligonucleotide chemistry and conjugation
  • Proficient in design and interpretation of analytical data including HIC, SEC, LC-MS, IEX, and RP
  • Experience with generation and characterization of antibody drug conjugates by multiple methodologies (Cys, Lys, Enzymatic)
  • Strong organizational skills and ability to manage multiple projects simultaneously, capability to prioritize, and drive in a fast-paced startup
    environment
  • This position requires an individual who is self-motivated, enthusiastic, hard-working, detail-oriented with demonstrated problem solving skills.
  • High-quality written and oral communication skills and the ability to excel in a collaborative environment are essential.

Tallac Therapeutics™ is an equal opportunity employer. All applicants should be legally entitled to work for any employer in the U.S. To apply for this position, please send your cover letter and resume to hr@tallactx.com

We are seeking a responsible and highly motivated scientist to join our Biology group. This position offers an opportunity to work with a small, dynamic team to support oncology and immuno-oncology drug discovery. Enthusiasm, communication, teamwork, and transparency are all key attributes for this position. The qualified candidate will have proficiency with basic tissue culture and molecular biology techniques and is eager to learn additional skills related to immunology and cancer biology. Tallac Therapeutics Inc. is a privately held immuno-oncology company advancing innovative therapeutic approaches in disease areas of unmet medical needs. Our core technology platform enables us to discover and develop next generation protein therapeutics for targeted immune activation.

Responsibilities

  • With guidance, design in vitro model systems for drug screening.
  • Independently execute experiments, analyze and interpret data, and report findings.
  • Maintain cultures of adherent and non-adherent cell lines and primary cells.
  • Provide support across multiple projects within the Biology group.
  • Maintain detailed records of studies performed.

Qualifications

  • Bachelor’s degree in relevant scientific discipline (i.e., molecular or cellular biology, immunology) with 3+ years of laboratory research experience.
  • Experience performing mammalian cell culture (sterile technique and passaging), in vitro cell-based assays, and molecular biology assays (DNA/RNA isolation and quantitative PCR) are required. Experience with multi-color flow cytometry is a plus.
  • Demonstrated ability to plan and execute experiments, analyze and interpret data, and report conclusions.
  • Must be a team player who possesses an eagerness to learn, can work independently, can problem solve, and manage time efficiently.
  • Excellent verbal and written communication skills.
  • Attention to detail is essential.

Tallac Therapeutics is an equal opportunity employer. All applicants should be legally entitled to work for any employer in the U.S. To apply for this position, please send your cover letter and resume to hr@tallactx.com.

We are seeking a responsible and highly motivated individual to join our Biology group. This position offers an opportunity to work with a small, dynamic team and contribute to the discovery of and advancing therapeutic leads. Communication, teamwork, and transparency are key attributes for this position. The qualified candidate will have proficiency with antibody-based assays such as ELISA, basic tissue culture and/ or molecular biology techniques. Candidate should be eager to learn additional skills related to antibody discovery, immunology, and cancer biology. Tallac Therapeutics Inc. is a privately held immuno-oncology company advancing innovative therapeutic approaches in disease areas of unmet medical needs. Our core technology platform enables us to discover and develop next generation protein therapeutics for targeted immune activation.

Responsibilities

  • Analyze samples from non-clinical toxicology and PK/PD studies.
  • Collaborate with research and development teams on other relevant bioassays.
  • Support antibody discovery efforts by maintaining mammalian cell cultures, serum titer tracking, screening and characterizing clones.
  • Independently execute experiments, analyze and interpret data, and report findings.
  • Provide support across multiple projects within the Biology group.
  • Maintain detailed records of studies performed.

Qualifications

  • Bachelors or MS in relevant scientific discipline (i.e., pharmacology, toxicology, molecular or cellular biology, immunology) with 3+ years of laboratory research experience.
  • Experience developing and successfully executing antibody-based assays, PK/PD assays, ADA bridging assays and immunogenicity assays.
  • Experience performing in vitro cell-based assays, and molecular biology assays (DNA/RNA isolation and PCR).
  • Working knowledge of aseptic technique culturing and passaging mammalian cells.
  • Demonstrated ability to plan and execute experiments, analyze, and interpret data, and report conclusions.
  • Must be a team player who possesses an eagerness to learn, can work independently, can problem solve, and manage time efficiently.
  • Excellent verbal and written communication skills.
  • Attention to detail is essential.

Tallac Therapeutics™ is an equal opportunity employer.  All applicants should be legally entitled to work for any employer in the U.S. To apply for this position, please send your cover letter and resume to hr@tallactx.com